Benchmarking the Intrinsic Activity of Transition Metal Oxides for the Oxygen Evolution Reaction with Advanced Nanoelectrodes.

The intrinsic activity assessment of transition metal oxides (TMOs) as key electrocatalysts for the oxygen evolution reaction (OER) has not been standardized due to uncertainties regarding their structure and composition, difficulties in accurately measuring their electrochemically active surface area (ECSA), and deficiencies in mass-transfer (MT) rates in conventional measurements. To address these issues, we utilized an electrodeposition-thermal annealing method to precisely synthesize single-particle TMOs with well-defined structure and composition. Concurrently, we engineered low roughness, spherical surfaces for individual particles, enabling precise measurement of their ECSA. Furthermore, by constructing a conductor-core semiconductor-shell structure, we evaluated the inherent OER activity of perovskite-type semiconductor materials, broadening the scope beyond just conductive TMOs. Finally, using single-particle nanoelectrode technique, we systematically measured individual TMO particles of various sizes for OER, overcoming MT limitations seen in conventional approaches. These improvements have led us to propose a precise and reliable approach to evaluating the intrinsic activity of TMOs, not only validating the accuracy of theoretical calculations but also revealing a strong correlation of OER activity on the melting point of TMOs. This discovery holds significant importance for future high-throughput material research and applications, offering valuable insights in electrocatalysis.

Effects of Citrobacter freundii on sturgeon: Insights from skin mucosal immunology and microbiota.

Skin mucus analysis has recently been used as a non-invasive method to evaluate for fish welfare. The present research study was conducted to examine the skin mucosal immunity and skin microbiota profiles of sturgeons infected with Citrobacter freundii. Our histology results showed that the thickness of the epidermal layer of skin remained thinner, and the number of mucous cells was significantly decreased in sturgeons after infection (p < 0.05). Total protein, alanine aminotransferase, aspartate aminotransferase, superoxide dismutase, and creatine kinase levels in the mucus showed biphasic pattern (decrease and then increase). Lactate dehydrogenase, lysozyme, and acid phosphatase activities in the mucus showed an increasing trend after infection. Furthermore, 16S rRNA sequencing also revealed that C. freundii infection also affected the diversity and community structure of the skin mucus microbiota. An increase in microbial diversity (p > 0.05) and a decrease in microbial abundance (p < 0.05) after infection were noted. The predominant bacterial phyla in the skin mucus were Proteobacteria, Fusobacteria, Bacteroidetes, Firmicutes, and Actinobacteria. Specifically, the relative abundance of Fusobacteria increased after infection. The predominant bacterial genera in the skin mucus were Cetobacterium, Pelomonas, Bradyrhizobium, Flavobacterium, and Pseudomonas. The relative abundance of Cetobacterium, Pseudomonas, and Flavobacterium increased after infection. Our current research findings will provide new insights into the theoretical basis for future research studies exploring the mechanism of sturgeon infection with C. freundii.

Advancements in NSCLC: From Pathophysiological Insights to Targeted Treatments.

With the global incidence of non-small cell lung cancer (NSCLC) on the rise, the development of innovative treatment strategies is increasingly vital. This review underscores the pivotal role of precision medicine in transforming NSCLC management, particularly through the integration of genomic and epigenomic insights to enhance treatment outcomes for patients. We focus on the identification of key gene mutations and examine the evolution and impact of targeted therapies. These therapies have shown encouraging results in improving survival rates and quality of life. Despite numerous gene mutations being identified in association with NSCLC, targeted treatments are available for only a select few. This paper offers an exhaustive analysis of the pathogenesis of NSCLC and reviews the latest advancements in targeted therapeutic approaches. It emphasizes the ongoing necessity for research and development in this domain. In addition, we discuss the current challenges faced in the clinical application of these therapies and the potential directions for future research, including the identification of novel targets and the development of new treatment modalities.

Indexing serum and mucous biochemical parameters of endangered Chinese sturgeon Acipenser sinensis with implications for health assessment.

The Chinese sturgeon (Acipenser sinensis) is a critically endangered aquatic fish. Health monitoring and welfare assessments are critical for the conservation of Chinese sturgeon. In this study, biochemical parameters of serum and skin mucus in Chinese sturgeon were examined to evaluate the potential biomarkers. Serum and mucous samples were obtained from Chinese sturgeon, and the levels of total protein (TP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), lactic acid (LD), acid phosphatase (ACP), lysozyme (LYZ), glucose (GLU), and cortisol were determined. The concentrations of ALT, AST, cortisol, and LYZ were significantly higher in the mucous group than those in the serum group (p < 0.05). In addition, the concentrations of ALP, ACP, LD, LDH, CK, and TP were significantly higher level in the serum group than those in the mucous group (p < 0.05). Moreover, the correlations between serum and mucous biochemical parameters were established. Statistical analysis showed a positive correlation between serum and skin mucous markers (ACP, cortisol, and LYZ). AST versus ALT in serum and mucus showed a significant positive correlation (p < 0.01). A significant positive correlation was found between cortisol and CK in mucus (p < 0.01). Moreover, LD versus LDH in serum showed a significant but weak positive correlation (p < 0.01). Principal component analysis revealed a complete separation between the serum and mucous groups, with the biomarkers that contributed the most being ALP, TP, ALT, and AST. This study provides baseline data and reference intervals for serum and mucous biochemical parameters in presumably healthy Chinese sturgeons. The current study has important implications for the development of conservation strategies and the conservation status of critically endangered species.

Biotene: Earth-Abundant 2D Material as Sustainable Anode for Li/Na-Ion Battery.

Natural ores are abundant, cost-effective, and environmentally friendly. Ultrathin (2D) layers of a naturally abundant van der Waals mineral, Biotite, have been prepared in bulk via exfoliation. We report here that this 2D Biotene material has shown extraordinary Li-Na-ion battery anode properties with ultralong cycling stability. Biotene shows 302 and 141 mAh g-1 first cycle-specific charge capacity for Li- and Na-ion battery applications with ∼90% initial Coulombic efficiency. The electrode exhibits significantly extended cycling stability with ∼75% capacity retention after 4000 cycles even at higher current densities (500-2000 mA g-1). Further, density functional theory studies show the possible Li intercalation mechanism between the 2D Biotene layers. Our work brings new directions toward designing the next generation of metal-ion battery anodes.

Calibration of the oscillation amplitude of quartz tuning fork-based force sensors with astigmatic displacement microscopy.

Quartz tuning forks and qPlus-based force sensors offer an alternative approach to silicon cantilevers for investigating tip-sample interactions in scanning probe microscopy. The high-quality factor (Q) and stiffness of these sensors prevent the tip from jumping to the contact, even at sub-nanometer amplitude. The qPlus configuration enables simultaneous scanning tunneling microscopy and atomic force microscopy, achieving spatial resolution and spectroscopy at the subatomic level. However, to enable precise measurement of tip-sample interaction forces, confidence in these measurements is contingent upon the accurate calibration of the spring constant and oscillation amplitude of the sensor. Here, we have developed a method called astigmatic displacement microscopy with picometer sensitivity.

Transcriptome analysis reveals dysfunction of the endoplasmic reticulum protein processing in the sonic muscle of small yellow croaker (Larimichthys polyactis) following noise exposure.

Noise pollution is increasingly prevalent in aquatic ecosystems, causing detrimental effects on growth and behavior of marine fishes. The physiological responses of fish to underwater noise are poorly understood. In this study, we used RNA-sequencing (RNA-seq) to study the transcriptome of the sonic muscle in small yellow croaker (Larimichthys polyactis) after exposure to a 120 dB noise for 30 min. The behavioral experiment revealed that noise exposure resulted in accelerated tail swimming behavior at the beginning of the exposure period, followed by loss of balance at the end of experiment. Transcriptomic analysis found that most highly expressed genes in the sonic muscle, including parvalbumin, slc25a4, and troponin C were related with energy metabolism and locomotor function. Further, a total of 1261 differentially expressed genes (DEGs) were identified, including 284 up-regulated and 977 down-regulated genes in the noise exposure group compared with the control group. Gene ontology (GO) analysis indicated that the most enriched categories of DEGs included protein folding and response to unfolding protein. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis found over-represented pathways including protein processing in the endoplasmic reticulum, chaperones and folding catalysts, as well as arginine and proline metabolism. Specifically, many genes related to fatty acid and collagen metabolism were up-regulated in the noise exposure group. Taken together, our results indicate that exposure to noise stressors alters the swimming behavior of croaker, inducing endoplasmic reticulum stress, disrupting lipid metabolism, and causing collagen degradation in the sonic muscle of L. polyactis.

Efficacy and safety of Xiao-ai-ping injection add-on therapy to chemotherapy in patients with non-small cell lung cancer: A systematic review and meta-analysis.

BACKGROUND: Xiao-ai-ping injection (XAPI) combined with chemotherapy has potential efficacy and less side effects in the treatment of non-small cell lung cancer (NSCLC). At present, there are many clinical studies on XAPI combined with chemotherapy in the treatment of NSCLC, but the results are different. The purpose of this study was to evaluate the efficacy and safety of XAPI combined with chemotherapy in the treatment of NSCLC by meta-analysis system. METHODS: The databases to be searched include PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang database, Chinese Scientific Journal Database, and so on. In addition, relevant journals and magazines will manually search in various fields as supplements. The search date is set from the establishment of the database until July 8, 2023. The 2 researchers will use Endnote X9 software for literature screening and data extraction and independently evaluate the quality. We then assessed the quality and risk of inclusion in the study and observed outcome indicators. RESULTS: A total of 28 trials were included in this study, 1947 patients with NSCLC (974 receiving XAPI combined chemotherapy and 973 receiving chemotherapy alone). The results of meta-analysis showed that: Objective tumor response rate of NSCLC (P < .00001). Improvement in Karnofsky performance score of NSCLC (P < .00001). Quality of life score of NSCLC (P < .00001). The result of CD3 + (P < .00001). The result of CD4 + (P < .00001). The result of CD8 + (P < .00001). The result of CD4+/CD8 + (P = .0001). Leukopenia (P < .00001). Thrombocytopenia (P < .00001). Hemoglobin decrease (P < .00001). Liver function (P = .04). Nausea and vomiting (P < .00001). CONCLUSION: Our meta-analyses demonstrated that XAPI adjunct with chemotherapy can improve the patient quality of life, reduce adverse reactions, and enhanced immune function, the treatment is effective and high safety. Which suggests that it might be used for NSCLC. However, a large sample of randomized controlled trials are needed to further study the long-term efficacy of XAPI.

Combination of Rapid Intrinsic Activity Measurements and Machine Learning as a Screening Approach for Multicomponent Electrocatalysts.

Machine learning (ML) coupled with quantum chemistry calculations predicts catalyst properties with high accuracy; however, ML approaches in the design of multicomponent catalysts primarily rely on simulation data because obtaining sufficient experimental data in a short time is difficult. Herein, we developed a rapid screening strategy involving nanodroplet-mediated electrodeposition using a carbon nanocorn electrode as the support substrate that enables complete data collection for training artificial intelligence networks in one week. The inert support substrate ensures intrinsic activity measurement and operando characterization of the irreversible reconstruction of multinary alloy particles during the oxygen evolution reaction. Our approach works as a closed loop: catalyst synthesis-in situ measurement and characterization-database construction-ML analysis-catalyst design. Using artificial neural networks, the ML analysis revealed that the entropy values of multicomponent catalysts are proportional to their catalytic activity. The catalytic activities of high-entropy systems with different components varied little, and the overall catalytic activity was greater than that of the medium-low-entropy system. These findings will serve as a guideline for the design of catalysts.

MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.

Myc target 1 (MYCT1), located at 6q25.2, is a crucial player in cancer development. While widely distributed in cells, its subcellular localization varies across different cancer types. As a novel c-Myc target gene, MYCT1 is subject to regulation by multiple transcription factors. Studies have revealed aberrant expression of MYCT1 in various cancers, impacting pivotal biological processes such as proliferation, apoptosis, migration, genomic instability, and differentiation in cancer cells. Additionally, MYCT1 plays a critical role in modulating tumor angiogenesis and remodeling tumor immune responses within the tumor microenvironment. Despite certain debated functions, MYCT1 undeniably holds significance in cancer development. In this review, we comprehensively examine the relationship between MYCT1 and cancer, encompassing gene structure, regulation of gene expression, gene mutation, and biological function, with the aim of providing valuable insights for cancer diagnosis and treatment.

Electrochemical Visualization of an Ion-Selective Membrane Using a Carbon Nanoelectrode.

Molecular and physical probes have been widely employed to investigate physicochemical properties and mechanisms of interfaces due to their ability to provide accurate measurements with temporal and spatial resolution. However, the direct measurement of electroactive species diffusion in ion-selective electrode (ISE) membranes and quantification of the water layer have been challenging due to the high impedance and optical opacity of polymer membranes. In the present work, carbon nanoelectrodes with ultrathin insulating encapsulation and good geometrical structure are reported as physical probes for direct electrochemical measurement of the water layer. The scanning electrochemical microscopy experiment exhibits positive feedback at the interface of the fresh ISE, and negative feedback after conditioning for 3 h. The thickness of the water layer was estimated to be ca. 13 nm. For the first time, we provide direct evidence that, during conditioning, the water molecules diffuse through the chloride ion selective membrane (Cl-ISM) until a water layer establishes at almost 3 h. Furthermore, the diffusion coefficient and concentration of oxygen molecules in the Cl-ISM are also directly electrochemical measured by introducing ferrocene (Fc) as a redox molecule probe. The oxygen concentration in the Cl-ISM decreases during conditioning, suggesting the diffusion of oxygen from ISM to the water layer. The proposed method can be used for the electrochemical measurement of solid contact, providing theoretical guidance and advice for the performance optimization of ISEs.

Enhancing the Electrode Gravimetric Capacity of Li1.2Mn0.4Ti0.4O2 Cathode Using Interfacial Carbon Deposition and Carbon Nanotube-Mediated Electrical Percolation.

Mn-based cation-disordered rocksalt oxides (Mn-DRX) are emerging as promising cathode materials for next-generation Li-ion batteries due to their high specific capacities and cobalt- and nickel-free characteristic. However, to reach the usable capacity, solid-state synthesized Mn-DRX materials require activation via postsynthetic ball milling, typically incorporating more than 20 wt % conductive carbon that adversely reduces the electrode-level gravimetric capacity. To address this issue, we first deposit amorphous carbon on the surface of the Li1.2Mn0.4Ti0.4O2 (LMTO) particles to increase the electrical conductivity by 5 orders of magnitude. Although the cathode material gravimetric first charge capacity reaches 180 mAh/g, its highly irreversible behavior leads to a first discharge capacity of 70 mAh/g. Subsequently, to ensure a good electrical percolation network, the LMTO material is ball-milled with a multiwall carbon nanotube (CNT) to obtain a 78.7 wt % LMTO active material loading in the cathode electrode (LMTO-CNT). As a result, a 210 mAh/g cathode electrode gravimetric first charge and 165 mAh/g first discharge capacity values are obtained, compared to the respective capacity values of 222 and 155 mAh/g for the LMTO material ball-milled with 20 wt % SuperP C65 electrode (LMTO-SP). After 50 cycles, LMTO-CNT delivers a 121 mAh/g electrode gravimetric discharge capacity, largely outperforming the value of 44 mAh/g of LMTO-SP. Our study demonstrates that while ball milling is necessary to achieve a significant amount of capacity of LMTO, a careful selection of additives, such as CNT, effectively reduces the required carbon quantity to achieve a higher electrode gravimetric discharge capacity.

Investigating the technology of UV nanosecond laser milling for cutting CFRP laminates.

An enhanced ultraviolet (UV) nanosecond laser milling cutting method is innovatively adopted to cut carbon fiber reinforced plastic (CFRP) composites. This paper aims to achieve a more efficient and facile way to cut the thicker sheet cutting mode. The technology of UV nanosecond laser milling cutting is studied in detail. The effects of milling mode and filling spacing on the cutting effect are explored in milling mode cutting. Cutting with the milling method can obtain a smaller heat-affected zone at the slit entrance and a shorter effective processing time. When the longitudinal milling method is adopted, the machining effect of the lower side of the slit is better when the filling spacing is 20 µm and 50 µm, with no burr or other defects. Additionally, the filling spacing below 50 µm can obtain a better machining effect. The coupled photochemical and photothermal effects of UV laser cutting CFRP are elucidated, and the experiments verify this phenomenon successfully. Overall, it is anticipated that this study can offer a practical reference for UV nanosecond laser milling cutting CFRP composites and make contributions to military fields.

Harnessing the LdCsm RNA Detection Platform for Efficient microRNA Detection.

In cancer diagnosis, diverse microRNAs (miRNAs) are used as biomarkers for carcinogenesis of distinctive human cancers. Thus, the detection of these miRNAs and their quantification are very important in prevention of cancer diseases in human beings. However, efficient RNA detection often requires RT-PCR, which is very complex for miRNAs. Recently, the development of CRISPR-based nucleic acid detection tools has brought new promises to efficient miRNA detection. Three CRISPR systems can be explored for miRNA detection, including type III, V, and VI, among which type III (CRISPR-Cas10) systems have a unique property as they recognize RNA directly and cleave DNA collaterally. In particular, a unique type III-A Csm system encoded by Lactobacillus delbrueckii subsp. bulgaricus (LdCsm) exhibits robust target RNA-activated DNase activity, which makes it a promising candidate for developing efficient miRNA diagnostic tools. Herein, LdCsm was tested for RNA detection using fluorescence-quenched DNA reporters. We found that the system is capable of specific detection of miR-155, a microRNA implicated in the carcinogenesis of human breast cancer. The RNA detection system was then improved by various approaches including assay conditions and modification of the 5'-repeat tag of LdCsm crRNAs. Due to its robustness, the resulting LdCsm detection platform has the potential to be further developed as a better point-of-care miRNA diagnostics relative to other CRISPR-based RNA detection tools.

Strong, flexible and UV-shielding composite polyvinyl alcohol films with wood cellulose skeleton and lignin nanoparticles.

The development of high-performance composite films using biomass materials have become a sought-after direction. Herein, a green method to fabricate strong, flexible and UV-shielding biological composite film from wood cellulose skeleton (WCS), lignin nanoparticles (LNPs) and polyvinyl alcohol (PVA) was described. In the work, WCS and LNPs were prepared by chemical treatment of wood veneer and Enzymatic lignin, respectively. Then, WCS was infiltrated with the LNPs/PVA mixtures and dried to obtain composite films. WCS enhanced the mechanical properties of the composite films, the tensile stress reached to 85.8 MPa and the tensile strain reached to 6.39 %. The composite films with LNPs blocked over 98 % of UV-light, the water absorption decreased by 30 %, and the thermal stabilities were also improved. These findings would provide some references for exploring high quality biological composite films.

Association between meteorological factors and the epidemics of influenza (sub)types in a subtropical basin of Southwest China.

BACKGROUND: The effects of climatic conditions on the prevalence of individual influenza (sub)types are not well understood in the subtropics. This study aims to evaluate the associations between meteorological factors and seasonal epidemics of A(H3N2), A(H1N1)pdm09, and type B influenza viruses, as well as to estimate the interactions between climatic variables in a subtropical basin region. METHODS: The seasonality of influenza (sub)types during 2010-2019 were characterized in Chengdu Plain Economic Zone, a densely populated and highly humid plain area in Sichuan Basin in subtropical Southwest China. Generalized additive models were adopted to assess the independent exposure-response relationship between meteorological variables and influenza prevalence. The interactions of meteorological variables were further estimated using bivariate response surface models and strata models. RESULTS: Our analyses indicated that the temperature, relative humidity, and absolute humidity have exhibited a major influence on influenza infection in Chengdu Plain Economic Zone. Low temperature was shown to promote the prevalence of A(H1N1)pdm09 and type B in winter-spring days at all levels of relative humidity. High risk of A(H3N2) infections was observed at low temperature or high temperature, and at higher relative humidity. Moreover, absolute humidity decreased or increased influenza (sub)type infections within different ranges. CONCLUSIONS: This study found different nonlinear relationships between meteorological factors and the seasonality of influenza (sub)types, as well as significant interactive effects between climatic variables, contributing to the research on the climate drivers of influenza prevalence in warm-humid basin regions in the subtropics.

Precise Polishing and Electrochemical Applications of Quartz Nanopipette-Based Carbon Nanoelectrodes.

Quartz nanopipette-based carbon nanoelectrodes (CNEs) have attracted extensive attention in nanoscale electrochemistry due to their simple and efficient fabrication, chemically inert materials, flexible size (down to a few nanometers), and ultrathin insulating encapsulation. However, these pristine CNEs usually have significantly irregular morphology on the surface, which greatly limits the applications where inlaid nanodisks are urgently needed. To address this critical issue, we have developed a new precise polishing strategy using paraffin coating protection (i.e., avoiding breakage of quartz materials) and real-time monitoring with a high impedance meter (i.e., indicating electrode exposure) to produce flat carbon nanodisk electrodes. The surface flatness of polished CNEs has been confirmed by a combination of scanning electron microscopy, fast-scan cyclic voltammetry, and scanning electrochemical microscopy. As compared to the expensive focused ion beam processing, this strategy is competitive in terms of the low cost and availability of the equipment and enables the preparation of polished CNEs with sufficiently small size. The flattened CNEs have been exemplified for grafting molecular catalysts to achieve the durable catalysis of reactive molecules or for immobilizing single-particle electrocatalysts to measure the intrinsic activity under sufficient mass-transfer rates.

Enhanced 2D finite element model and its application in laser cutting of carbon fiber reinforced plastic composites.

A tailored 2D finite element model (FEM) is proposed to describe the temperature distribution and stress distribution by the UV nanosecond pulsed laser cutting of carbon fiber reinforced plastic (CFRP) composites. This model coupled thermodynamic and thermal stress and considers the heat conduction, thermal stress, and heat flux effects during the UV laser cutting of CFRP composites. In this study, the main mechanism of UV laser cutting of CFRP is elucidated, such as pressure gradient, plasma, and vaporization effects. The temperature field and stress field in a single pulse period are successfully simulated based on these theoretical models. We believe that this research will supply a theoretical reference for the UV laser cutting of CFRP composites and pave the way for applications in the aerospace industry in the future.

Multi-omics reveals response mechanism of liver metabolism of hybrid sturgeon under ship noise stress.

Underwater noise from ship engines can affect the metabolism and immune system of various fish species. Meanwhile, changes in the metabolic pathways in liver are important for fish to adapt to adverse environments. We used a combined multi-omics analysis to investigate the response mechanism of hybrid sturgeon to continuously played ship noise. A control group and a noise group (simulated ship noise: 12 h) were set up, and liver tissues were extracted for high-throughput transcriptome and metabolome sequencing. The results show that a total of 588 differentially expressed genes (DEGs) and 58 DEGs metabolites were detected. The joint analysis of transcriptome and metabolome showed that under noise stress, apoptosis and cell motility were intensified, DNA replication, RNA transcription and translation, and protein synthesis were inhibited, and lipid metabolism, nucleotide metabolism, and vitamin D3 metabolic pathways were also inhibited. Interestingly, the initiation of a partial immune responses ensured their normal immunity abilities. Moreover, material and energy requirements of the organism under noise stress were guaranteed by upregulation of carbohydrate and amino acid metabolic pathways.

Brushed Metals for Rechargeable Metal Batteries.

Battery designs are swiftly changing from metal-ion to rechargeable metal batteries. Theoretically, metals can deliver maximum anode capacity and enable cells with improved energy density. In practice, these advantages are only possible if the parasitic surface reactions associated with metal anodes are controlled. These undesirable surface reactions are responsible for many troublesome issues, like dendrite formation and accelerated consumption of active materials, which leads to anodes with low cycle life or even battery runaway. Here, a facile and solvent-free brushing method is reported to convert powders into films atop Li and Na metal foils. Benefiting from the reactivity of Li metal with these powder films, surface energy can be effectively tuned, thereby preventing parasitic reaction. In-operando study of P2 S5 -modified Li anodes in liquid electrolyte cells reveals a smoother electrode contour and more uniform metal electrodeposition and dissolution behavior. The P2 S5 -modified Li anodes sustain ultralow polarization in symmetric cell for >4000 h, ≈8× longer than bare Li anodes. The capacity retention is ≈70% higher when P2 S5 -modified Li anodes are paired with a practical LiFePO4 cathode (≈3.2 mAh cm-2 ) after 340 cycles. Brush coating opens a promising avenue to fabricate large-scale artificial solid-electrolyte-interphase directly on metals without the need for organic solvent.